Volume 6, Issue 4, December 2020, Page: 433-436
Beckwith-Wiedemann Syndrome: A Case Report at the Gynaeco-Obstetric and Pediatric Hospital in Yaounde, Cameroon
Daniel Armand Kago Tague, Department of Paediatrics, Faculty of Medicine and Biomedical Sciences, the University of Yaounde I, Yaounde, Cameroon
Evelyn Mah, Department of Paediatrics, Faculty of Medicine and Biomedical Sciences, the University of Yaounde I, Yaounde, Cameroon
Félicitee Nguefack, Department of Paediatrics, Faculty of Medicine and Biomedical Sciences, the University of Yaounde I, Yaounde, Cameroon
Georges Pius Kamsu Moyo, Department of Paediatrics, Faculty of Medicine and Biomedical Sciences, the University of Yaounde I, Yaounde, Cameroon
Lionel Loic Kago Tcheyanou, Department of Paediatrics, Faculty of Medicine and Biomedical Sciences, the University of Yaounde I, Yaounde, Cameroon
Faustin Mouafo, Department of Surgery, Faculty of Medicine and Biomedical Sciences, the University of Yaounde I, Yaounde, Cameroon
Received: Sep. 28, 2020;       Accepted: Oct. 15, 2020;       Published: Oct. 23, 2020
DOI: 10.11648/j.ajp.20200604.17      View  68      Downloads  20
Abstract
Beckwith-Wiedemann syndrome is a rare congenital syndrome, but one of the most common among overgrowth syndromes. It was described firstly by Beckwith in 1963. The incidence of BWS is about 1:13 700 births, with an equal sex distribution. It is characterized by macrosomia, macroglossia, omphalocele and anterior abdominal wall defects. It is a complex multigenic disorder caused by dysregulation of the gene printed on chromosome 11p. 15. A relationship has been established between assisted fertilization methods and its occurrence. This syndrome predisposes to childhood cancer. Its incidence is not known in developing countries such as Cameroon due to the rarity of reported cases, variability in the presentation of the syndrome, financial constraints and lack of access to genetic and molecular studies. In our opinion, we are reporting the first case of Beckwith-Wiedemann syndrome in our country. We present here the case of a newborn female baby delivered at the gyneco-obstetric and pediatric hospital in Yaoundé and admitted to our neonatology unit. The diagnosis was made on the basis of clinical signs suggestive of Beckwith-Wiedemann syndrome. She presented an omphalocele diagnosed on antenatal ultrasound, macrosomia, macroglossia and ear abnormalities. The case is presented to raise awareness and highlight the particularity of the management of this rare disease.
Keywords
Beckwith-Wiedemann, Macrosomia, Macroglossia, Omphalocele
To cite this article
Daniel Armand Kago Tague, Evelyn Mah, Félicitee Nguefack, Georges Pius Kamsu Moyo, Lionel Loic Kago Tcheyanou, Faustin Mouafo, Beckwith-Wiedemann Syndrome: A Case Report at the Gynaeco-Obstetric and Pediatric Hospital in Yaounde, Cameroon, American Journal of Pediatrics. Vol. 6, No. 4, 2020, pp. 433-436. doi: 10.11648/j.ajp.20200604.17
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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