Volume 6, Issue 4, December 2020, Page: 386-391
A Determination of the Serum Ascitic Fluid Albumin Concentration Gradient in Children with Chronic Liver Disease and Nephrotic Syndrome
Md. Zakaria, Depterment of Paediatrics, Sunamgong Sadar Hospital, Sunamgong, Sylhet, Bangladesh
ASM Bazlul Karim, Depterment of Paediatric Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mohammad Monir Hossain, Depterment of Paediatric Neurology, Bangabandhu Sheik Mujib Medical University (OSD), Dhaka, Bangladesh
Md. Wahiduzzaman Mazumder, Depterment of Paediatric Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Md. Mostafa Zaman, Depterment of Paediatrics, M Abdur Rahim Medical College (MARMC), Dinajpur, Bangladesh
Nadira Parvin, Depterment of Pharmacology and Therapeutics, TMSS Medical College, Bogura, Bangladesh
Received: Feb. 5, 2020;       Accepted: Apr. 23, 2020;       Published: Sep. 30, 2020
DOI: 10.11648/j.ajp.20200604.11      View  41      Downloads  25
Abstract
This prospective cross sectional study was carried out in the Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka Medical College Hospital and Dhaka Shishu Hospital, Dhaka for a period of one year and six months starting from July 2012 to December 2013. The main objective of the study was to determine the serum ascitic fluid albumin concentration gradient in children with chronic liver disease and nephrotic syndrome. A total of 55 children were studied. Among them, 31 children with chronic liver disease with ascites were designated as Group I and rest 24 nephrotic syndrome children with ascites were designated as group II. The mean age of the children was 8.3±3.6 years ranging from 1.0-15.0 years. The mean age of the male patient was 8.0±3.6 years and that of female patients was 9.3±3.5 years. No statistically significant mean age difference was found between male and female patients (p>0.05), although female patients had a bit higher mean age than male patients. The mean age of the group I patients was 9.2±3.7 years ranging from 1.0-14.0 years and group II patients was 7.2±3.2 ranging from 2.0 to 15.0 years and the mean age difference between two groups patients was statistically significant (p<0.05) indicated that patients with chronic liver disease had higher age than patients with nephrotic syndrome. Chronic liver diseases patients where liver biopsy could not be performed to ascertain the exact nature of the disease were labeled as unclassified chronic liver disease. The aetiology of chronic liver diseases of the group I patients. Out of 31 patients, highest percentage of patients were of unknown etiology 17 (54.9%) followed by hepatitis B virus 7 (22.6%) and Wilson’s disease 5 (16.1%). It was evident that 24 (77.4%) had serum bilirubin >1.2 mg/dl, serum ALT >40 IU/L was 25 (80.6%), prothrombin time more than 3 second than control 23 (74.2%) and serum albumin less than 3.5 mg/dl was 24 (77.4%). The mean serum albumin was 2.8±0.5 mg/dl in group I patients and 1.7±0.4 mg/dl in group II patients. The albumin in ascitic fluid was 1.2±0.4 mg/dl in group I patients and 0.9±0.3 mg/dl in group II patients. Similarly, serum-ascites albumin gradient was 1.6±0.5 in group I and 0.8±0.2 in group II. It was evident that mean serum albumin, ascetic albumin as well as serum-ascites albumin gradient was significantly higher among the group I patients compared to group II patients (p<0.001).
Keywords
Paediatric, Albumin, Nephrotic, Biochemical
To cite this article
Md. Zakaria, ASM Bazlul Karim, Mohammad Monir Hossain, Md. Wahiduzzaman Mazumder, Md. Mostafa Zaman, Nadira Parvin, A Determination of the Serum Ascitic Fluid Albumin Concentration Gradient in Children with Chronic Liver Disease and Nephrotic Syndrome, American Journal of Pediatrics. Vol. 6, No. 4, 2020, pp. 386-391. doi: 10.11648/j.ajp.20200604.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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