Volume 6, Issue 3, September 2020, Page: 199-206
Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia
Putilina Marina, Department of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Teplova Nataliya, Department of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Dvornikov Anton, Department of Dermatology and Venereology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Received: Apr. 18, 2020;       Accepted: May 6, 2020;       Published: May 15, 2020
DOI: 10.11648/j.ajp.20200603.15      View  28      Downloads  18
Abstract
In recent years, an increase in dysmenorrhea among adolescents has been observed worldwide. Oral contraceptives are used in gynaecological practice to correct this condition. However, the prescription of drugs belonging to this group often misses the risk of developing vascular complications, such as cerebral venous thrombosis and cerebral venous infarction. Due to the growing percentage of patients with congenital genetic mutations, it is relevant and reasonable to consider the risk factors and clinical signs of venous infarction in adolescents. First, it is necessary to exclude congenital thrombophilia, factor V Leiden and prothrombin G20210A gene mutations, and deficiency of proteins C, S and antithrombin. Of particular notice are the young patients and adolescents with complaints of a first-time, intense, poorly treatable headache (or headache in anamnesis), changes in the eye fundus (edematous, hyperemic optic disks; dilated, plethoric veins in the fundus of the eye). In such cases, a thorough medical history is extremely important, including, in particular, detection of an infectious process, traumatic brain injury, venous thrombosis of any localization; the use of drugs (especially hormonal ones) that can provoke the development of a hypercoagulable state; and investigation of the family history. These measures will help to prevent development of a cerebral venous circulation disorder (venous infarction).
Keywords
Venous Infarction, Thrombophilia, Oral Contraceptives
To cite this article
Putilina Marina, Teplova Nataliya, Dvornikov Anton, Venous Cerebral Infarction Caused by Intake of Hormonal Contraceptives in Adolescents with Congenital Thrombophilia, American Journal of Pediatrics. Vol. 6, No. 3, 2020, pp. 199-206. doi: 10.11648/j.ajp.20200603.15
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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