| Peer-Reviewed

The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia

Received: 14 June 2021     Accepted: 23 June 2021     Published: 10 July 2021
Views:       Downloads:
Abstract

Background: Short stature is a public health problem that, by definition, affects 2.5% of the population around the world, and higher rates in some areas. Celiac disease is one of the causes of short stature, it occurs with multiple mechanisms. And it is one of the causes that can be treated and thus the final length improvement, especially with the early start of treatment. Detection of celiac disease serologically is easy and cost-effective. Aims: To determine the prevalence of antiTTG-IGA antibody positivity in patients who meet the standard definition of short stature. Methods: A cross-sectional study that included 132 short children over two years of age attending the Pediatric endocrinology Clinic at Tishreen University Hospital from the beginning of 2016 until the end of 2019. The data of the patients attending the clinic with complaints of short stature was reviewed and the patients with antiTTG-IGA antibodies were identified and their data related to anemia and clinical symptoms were analyzed. Results: The number of short children included in the study was 132 children (69 males and 63 females), 10 of whom had positive antiTTG-IGA antibodies that were 7.6%. Digestive symptoms or anemia were not statistically significant in predicting the presence of celiac disease. It was found that the near-normal BMI and the absence of severe weight growth failure do not exclude the presence of celiac disease. Conclusion: Celiac disease is an important cause of short stature that is difficult to predict through clinical symptoms, which requires for titration of antiTTG-IGA antibodies in all children with short stature.

Published in American Journal of Pediatrics (Volume 7, Issue 3)
DOI 10.11648/j.ajp.20210703.15
Page(s) 117-120
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Celiac Disease, Short Stature, Failure to Thrive, Body Mass Index, Anti Tissue Transglutaminase

References
[1] Husby, S., Koletzko, S., Korponay-Szabó, I. R., Mearin, M. L., Phillips, A., Shamir, R.,... & ESPGHAN Gastroenterology Committee. (2012). European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. Journal of pediatric gastroenterology and nutrition, 54 (1), 136-160.
[2] Green, P. H., & Cellier, C. (2007). Celiac disease. New england journal of medicine, 357 (17), 1731-1743.
[3] Cataldo, F., & Montalto, G. (2007). Celiac disease in the developing countries: a new and challenging public health problem. World journal of gastroenterology: WJG, 13 (15), 2153.
[4] van Rijn JC, Grote FK, Oostdijk W, Wit JM. Short stature and theprobability of celiac disease, in the absence of gastrointestinalsymptoms. Arch Dis Child. 2004; 89: 882–3.
[5] Bhadada, S. K., Bhansali, A., Kochhar, R., Menon, A. S., Sinha, S. K., Dutta, P., & Nain, C. K. (2008). Does every short stature child need screening for celiac disease?. Journal of gastroenterology and hepatology, 23 (8pt2), e353-e356.
[6] Al-Jurayyan, N. A., Al Nemri, A. M., Al Jurayyan, A. N., & Assiri, A. M. (2013). Celiac disease in children with short stature: A hospital based study. Journal of Taibah University Medical Sciences, 8 (2), 93-96.
[7] Queiroz, M. S., Nery, M., Cancado, E. L., Gianella-Neto, D., & Liberman, B. (2004). Prevalence of celiac disease in Brazilian children of short stature. Brazilian journal of medical and biological research, 37 (1), 55-60.
[8] Nusier, M. K., Brodtkorb, H. K., Rein, S. E., Odeh, A., Radaideh, A. M., & Klungland, H. (2010). Serological screening for celiac disease in schoolchildren in Jordan. Is height and weight affected when seropositive?. Italian journal of pediatrics, 36 (1), 1-6.‏
[9] Jansen, M. A., Kiefte-de Jong, J. C., Gaillard, R., Escher, J. C., Hofman, A., Jaddoe, V. W.,... & Moll, H. A. (2015). Growth Trajectories and Bone Mineral Density in Anti-Tissue Transglutaminase Antibody–positive Children: The Generation R Study. Clinical Gastroenterology and Hepatology, 13 (5), 913-920.
[10] Krupa-Kozak, U. (2014). Pathologic bone alterations in celiac disease: etiology, epidemiology, and treatment. Nutrition, 30 (1), 16-24.‏
[11] Botero-López, J. E., Araya, M., Parada, A., Méndez, M. A., Pizarro, F., Espinosa, N., Canales, P., & Alarcón, T. (2011). Micronutrient deficiencies in patients with typical and atypical celiac disease. Journal of pediatric gastroenterology and nutrition, 53 (3), 265–270.
[12] Boersma, B., Houwen, R. H. J., Blum, W. F., Van Doorn, J., & Wit, J. M. (2002). Catch-up growth and endocrine changes in childhood celiac disease. Hormone Research in Paediatrics, 58 (Suppl. 1), 57-65.
[13] Rostami, K., Steegers, E. A. P., Wong, W. Y., Braat, D. D., & Steegers-Theunissen, R. P. M. (2001). Coeliac disease and reproductive disorders: a neglected association. European Journal of Obstetrics & Gynecology and Reproductive Biology, 96 (2), 146-149.
[14] Ch’ng, C. L., Jones, M. K., & Kingham, J. G. (2007). Celiac disease and autoimmune thyroid disease. Clinical medicine & research, 5 (3), 184-192.
[15] Delvecchio, M., De Bellis, A., Francavilla, R., Rutigliano, V., Predieri, B., Indrio, F.,... & Iughetti, L. (2010). Anti-pituitary antibodies in children with newly diagnosed celiac disease: a novel finding contributing to linear-growth impairment. The American journal of gastroenterology, 105 (3), 691.
[16] Jericho, H., Sansotta, N., & Guandalini, S. (2017). Extraintestinal manifestations of celiac disease: effectiveness of the gluten-free diet. Journal of pediatric gastroenterology and nutrition, 65 (1), 75-79.
[17] Reilly, N. R., Aguilar, K., Hassid, B. G., Cheng, J., DeFelice, A. R., Kazlow, P.,... & Green, P. H. (2011). Celiac disease in normal-weight and overweight children: clinical features and growth outcomes following a gluten-free diet. Journal of pediatric gastroenterology and nutrition, 53 (5), 528-531.
[18] Sempe M. Auxologie. Methode et sequences. Paris: Y Theraplix; 1979.
[19] https://www.unicef.org/mena/reports/syria-crisis-fast-facts.
Cite This Article
  • APA Style

    Mohammad Daaboul, Ahamad Chreitah, Ali Mohamed. (2021). The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia. American Journal of Pediatrics, 7(3), 117-120. https://doi.org/10.11648/j.ajp.20210703.15

    Copy | Download

    ACS Style

    Mohammad Daaboul; Ahamad Chreitah; Ali Mohamed. The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia. Am. J. Pediatr. 2021, 7(3), 117-120. doi: 10.11648/j.ajp.20210703.15

    Copy | Download

    AMA Style

    Mohammad Daaboul, Ahamad Chreitah, Ali Mohamed. The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia. Am J Pediatr. 2021;7(3):117-120. doi: 10.11648/j.ajp.20210703.15

    Copy | Download

  • @article{10.11648/j.ajp.20210703.15,
      author = {Mohammad Daaboul and Ahamad Chreitah and Ali Mohamed},
      title = {The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia},
      journal = {American Journal of Pediatrics},
      volume = {7},
      number = {3},
      pages = {117-120},
      doi = {10.11648/j.ajp.20210703.15},
      url = {https://doi.org/10.11648/j.ajp.20210703.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20210703.15},
      abstract = {Background: Short stature is a public health problem that, by definition, affects 2.5% of the population around the world, and higher rates in some areas. Celiac disease is one of the causes of short stature, it occurs with multiple mechanisms. And it is one of the causes that can be treated and thus the final length improvement, especially with the early start of treatment. Detection of celiac disease serologically is easy and cost-effective. Aims: To determine the prevalence of antiTTG-IGA antibody positivity in patients who meet the standard definition of short stature. Methods: A cross-sectional study that included 132 short children over two years of age attending the Pediatric endocrinology Clinic at Tishreen University Hospital from the beginning of 2016 until the end of 2019. The data of the patients attending the clinic with complaints of short stature was reviewed and the patients with antiTTG-IGA antibodies were identified and their data related to anemia and clinical symptoms were analyzed. Results: The number of short children included in the study was 132 children (69 males and 63 females), 10 of whom had positive antiTTG-IGA antibodies that were 7.6%. Digestive symptoms or anemia were not statistically significant in predicting the presence of celiac disease. It was found that the near-normal BMI and the absence of severe weight growth failure do not exclude the presence of celiac disease. Conclusion: Celiac disease is an important cause of short stature that is difficult to predict through clinical symptoms, which requires for titration of antiTTG-IGA antibodies in all children with short stature.},
     year = {2021}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - The Prevalence of Positivity of Anti Tissue Transglutaminase in Patients with Short Stature in Pediatric Endocrinology Clinic of Tishreen Hospital in Lattakia
    AU  - Mohammad Daaboul
    AU  - Ahamad Chreitah
    AU  - Ali Mohamed
    Y1  - 2021/07/10
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajp.20210703.15
    DO  - 10.11648/j.ajp.20210703.15
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 117
    EP  - 120
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20210703.15
    AB  - Background: Short stature is a public health problem that, by definition, affects 2.5% of the population around the world, and higher rates in some areas. Celiac disease is one of the causes of short stature, it occurs with multiple mechanisms. And it is one of the causes that can be treated and thus the final length improvement, especially with the early start of treatment. Detection of celiac disease serologically is easy and cost-effective. Aims: To determine the prevalence of antiTTG-IGA antibody positivity in patients who meet the standard definition of short stature. Methods: A cross-sectional study that included 132 short children over two years of age attending the Pediatric endocrinology Clinic at Tishreen University Hospital from the beginning of 2016 until the end of 2019. The data of the patients attending the clinic with complaints of short stature was reviewed and the patients with antiTTG-IGA antibodies were identified and their data related to anemia and clinical symptoms were analyzed. Results: The number of short children included in the study was 132 children (69 males and 63 females), 10 of whom had positive antiTTG-IGA antibodies that were 7.6%. Digestive symptoms or anemia were not statistically significant in predicting the presence of celiac disease. It was found that the near-normal BMI and the absence of severe weight growth failure do not exclude the presence of celiac disease. Conclusion: Celiac disease is an important cause of short stature that is difficult to predict through clinical symptoms, which requires for titration of antiTTG-IGA antibodies in all children with short stature.
    VL  - 7
    IS  - 3
    ER  - 

    Copy | Download

Author Information
  • Department of Pediatrics, Tishreen University Hospital, Lattakia, Syria

  • Department of Pediatrics, Tishreen University Hospital, Lattakia, Syria

  • Department of Pediatrics, Tishreen University Hospital, Lattakia, Syria

  • Sections