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The Beneficial Role of Probiotics in the Maintenance of Immunologic Equilibrium for Functional Gastrointestinal Disorders in Infancy

In the human colon commensal bacteria and immune cells interact regularly in a stable environment to keep the immune system functioning normally. The balance between immunological tolerance and immunogenicity is maintained by a complex network of pathways that are dependent on immune system-microbiota cross-talk. To modify certain immune activities and immunological homeostasis, probiotic bacteria can interact with and stimulate intestinal immune cells as well as commensal microflora. Probiotic microorganisms have crucial immunomodulatory and health-promoting characteristics, according to growing research. Therefore, using probiotics might be a worthwhile strategy for enhancing immune system functions. Few research has been published so far on the probiotics' favorable immune-modulating effects. However, a great deal more has been published that are primarily concerned with their nutritional and metabolic characteristics. As a result, the processes underlying the interaction between probiotics and host immune cells have only been partially explained. In order to better understand how probiotic bacteria and immune cells interact to enhance immune functions, the current review attempts to compile and describe the most recent research findings and their implications. As a result, a description of the probiotic bacteria's currently understood immunomodulatory processes for enhancing the human immune system is given.

Immune Cells, Probiotics, Human Health, Beneficial Microbes, Microbial Modulation Effects, Immune System, Immune Response, Functional Gastrointestinal Disorders

Manirul Haque Tarafder, Mofizul Islam, Mst Tanjila Momotaj, Fatema Farzana, Prahlad Kumar Shil, et al. (2023). The Beneficial Role of Probiotics in the Maintenance of Immunologic Equilibrium for Functional Gastrointestinal Disorders in Infancy. American Journal of Pediatrics, 9(4), 193-203.

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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